Nick Spencer

While in college, Spencer wrote three pitches to Marvel Comics soon after the Marvel Knights imprint launched in 1998. According to Spencer, "Joe [Quesada] didn’t like the first two but the third one was a Black Cat pitch that was a Jackie Brown kind of Tarantino-esque thing. He said he liked that one but they weren’t going to do anything with anybody new at the time." After another pitch was rejected, this time by Oni Press, Spencer went on to work in politics. He twice ran for the Cincinnati City Council as a candidate of the progressive Charter Party. Spencer also worked for a Democratic politician. He later moved to New York City and successfully pitched Existence 2.0 to Jim Valentino of Image Comics. The first issue was released in July 2009. A second miniseries, Existence 3.0, followed in November. In 2010, Paramount Pictures acquired the rights to Existence 2.0, and a film was in development through Platinum Dunes with Miles Millar and Alfred Gough to adapt and executive produce. Spencer also wrote Forgetless and Shuddertown at Image. An A.V. Club review of Shuddertown stated that Spencer "has become one of the finest practitioners" of crime noir in comics.

Spencer's first ongoing series, Morning Glories, was released in August 2010, that same year, he wrote a seven-part Jimmy Olsen co-feature for DC Comics beginning in September's Action Comics #893, which concluded in a one-shot (released March 30, 2011), and a T.H.U.N.D.E.R. Agents monthly series that debuted that November.

In 2011 he took over as the writer of Supergirl in January with issue #60, but DC announced two months later that he would only be co-scripting one issue. Spencer wrote Iron Man 2.0, a War Machine ongoing series for Marvel Comics which debuted that February. He also took over writing duties on Secret Avengers from Ed Brubaker with issue #13. It was announced at the 2011 Emerald City Comic Con that Spencer had signed an exclusive contract with Marvel, one that would allow him to continue writing his existing titles at both DC and Image.

In 2011 Spencer was one of three writers that worked on Ultimate Comics Universe Reborn, a relaunch of Marvel Comics' Ultimate Marvel line, along with Jonathan Hickman and Brian Michael Bendis. Spencer wrote Ultimate Comics X-Men.

In 2016 he become the writer of the ongoing series Captain America:Steve Rogers, in which Captain America has been replaced by a version of himself loyal to Hydra. In 2017, Spencer wrote the miniseries Secret Empire. The series was a commercial success, with issues #0 and 1 being the third best-selling comic books of April and May, respectively.

In March 2018, it was announced that Spencer would be writing a relaunched Amazing Spider-Man series that would premiere that year, replacing long-time writer Dan Slott, as part of the Fresh Start relaunch that July.