Spider-Man 2099

Miguel O'Hara, an engineer of Irish and Mexican descent, was born after his mother Conchata had an affair with her husband's boss Tyler Stone, though grew up believing his stepfather was also his biological father. As an adult, he worked for Alchemax. He was less than pleased at the corporation's vast control over the city. A genius in the field of genetics, he was being pressured by Tyler Stone to test a process to imprint genetic codes into human physiology.

When a coworker of Miguel's died in the test, he went to Stone and attempted to hand in his notice. Stone gave and Miguel accepted a drink which, unknown to Miguel had been laced with the highly addictive hallucinogenic drug that bonds to the victim's DNA, called Rapture. In an attempt to rid himself of the hallucinogen, Miguel decided to try the genetic procedure, which had killed Sims, on himself, as he had input his own original genetic code as a baseline. The process was sabotaged by his supervisor, Aaron Delgato, in the attempt to kill him (the incident would be covered up as an accident). Miguel survived the process; his DNA was spliced with the genes of a spider and gained several powers.