When Peter Parker was bitten by the radioactive spider that gave him his powers, it also bit Cindy Moon. After having been hidden for years by Ezekiel from the Inheritors, she left his bunker and became the hero Silk.
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When high school student Cindy Moon was attending a public exhibition demonstrating the safe handling of nuclear laboratory waste materials, sponsored by the General Techtronics Corporation, a spider irradiated by a particle accelerator used in the demonstration, bit Peter Parker on the hand and fell from his hand, it then bit Cindy in her ankle before dying. The first manifestation of her powers happened when her uncontrollable organic webbing accidentally caused her to web up her parents. A man by the name of Ezekiel Sims came and took Cindy away. He trained Cindy in the use of her powers until he realized the totemic predator Morlun was tracking her. He then locked her away in a room that blocks Morlun's detection at the bottom of his tower to protect her from him. This bunker had years worth of food, books, and tapes on the outside world which Cindy watched every day. She knew the code to leave at anytime but, knowing the consequences, she decided to stay put despite the horrible boredom.
Cindy's story was revealed to Peter Parker thirteen years later after the Orb unleashed several of the Watcher's secrets to the world. Overwhelmed by this revelation, he went to free Cindy. She tried to warn him about Morlun and the Inheritors, but Peter opened the door anyway. She attacked him for dooming the Spider-Verse to Morlun and his family. Peter tells her that Morlun is dead, and after realizing she was free, Cindy made an improvised costume of webs and explored the city as Silk.