Simon Meke was a mere assistant at a New York museum when he began having aspirations of super-villainy. Inspired by the various ages of man, he developed the criminal identity of Isbisa, the name consisting of the first letter in each age (Iron, Steel, Bronze, Ice, Stone, Atomic). His first crime was an ambitious attempt to steal an atomic bomb. Anticipating opposition from the newly-formed All-Winners Squad, he began plotting a complex plan to prevent them from stopping him in 1945.
